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<p>Biosensors based on DNA self-assembled monolayers (DNA-SAMs) combined with electrochemical transducers have shown great potential to serve an important role in simple, accurate and inexpensive genetic analysis relevant to many fields. Recently we have reported on observing a significant change in the viscoelasticity of such DNA layers immobilized on gold electrodes, upon redox switching of certain metal complexes at a millisecond time scale using an electrochemical quartz crystal microbalance (EQCM). In this study we have performed chronoamperometry on single stranded and double stranded DNA/6-mercapto-1-hexanol (MCH) mixed SAMs on gold electrodes in the presence of hexaammine ruthenium(III) (RuHex) to monitor the DNA modification with cis-diammine dichloroplatinum(II) (cisplatin). Our EQCM studies confirmed that the redox response of electrostatically bound RuHex is capable of providing quantitative information regarding the extent of DNA cross-linking with cisplatin. We believe that this method can be used in studies to test the interactions of cancer chemotherapeutic medications like cisplatin with ss &amp; dsDNA and ultimately be a new technology for rapid screening of such potential drug candidates that are able to penetrate the blood-brain barrier and interact with DNA in order to inhibit cancer cell growth of brain tumor tissue by forming DNA adducts.</p>
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Galagedera, S. K. K.; Flechsig, Gerd-Uwe (2020): Detection of the level of DNA cross-linking with cisplatin by electrochemical quartz crystal microbalance. Journal of Electroanalytical Chemistry 862, 113992. DOI: 10.1016/j.jelechem.2020.113992
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The website of Coburg University of Applied Sciences was translated using translation software provided by a third-party provider such as DeepL. The official text is the German version of the website. No liability is assumed, either explicitly or implicitly, for the accuracy, reliability, or correctness of the translations into another language.

Detection of the level of DNA cross-linking with cisplatin by electrochemical quartz crystal microbalance

Biosensors based on DNA self-assembled monolayers (DNA-SAMs) combined with electrochemical transducers have shown great potential to serve an important role in simple, accurate and inexpensive genetic analysis relevant to many fields. Recently we have reported on observing a significant change in the viscoelasticity of such DNA layers immobilized on gold electrodes, upon redox switching of certain metal complexes at a millisecond time scale using an electrochemical quartz crystal microbalance (EQCM). In this study we have performed chronoamperometry on single stranded and double stranded DNA/6-mercapto-1-hexanol (MCH) mixed SAMs on gold electrodes in the presence of hexaammine ruthenium(III) (RuHex) to monitor the DNA modification with cis-diammine dichloroplatinum(II) (cisplatin). Our EQCM studies confirmed that the redox response of electrostatically bound RuHex is capable of providing quantitative information regarding the extent of DNA cross-linking with cisplatin. We believe that this method can be used in studies to test the interactions of cancer chemotherapeutic medications like cisplatin with ss & dsDNA and ultimately be a new technology for rapid screening of such potential drug candidates that are able to penetrate the blood-brain barrier and interact with DNA in order to inhibit cancer cell growth of brain tumor tissue by forming DNA adducts.

Titel:

Detection of the level of DNA cross-linking with cisplatin by electrochemical quartz crystal microbalance

Veröffentlichungsdatum:

19.02.2020

Publikationsart:

Zeitschriftenbeiträge

Forschungsschwerpunkt:

HRK Schwerpunkt Gesundheit analysieren und fördern

Medien:

Journal of Electroanalytical Chemistry

DOI:

https://doi.org/10.1016/j.jelechem.2020.113992

Weblink:

Heft:

Band:

862

Artikelnummer:

113992

ISBN:

1572-6657

Autoren:

S. K. K. Galagedera, Gerd-Uwe Flechsig

Medien:

Journal of Electroanalytical Chemistry

Herausgeber:

Elsevier

Seiten:

Open Access:

Peer reviewed:

Ja

Zitierung:

Galagedera, S. K. K.; Flechsig, Gerd-Uwe (2020): Detection of the level of DNA cross-linking with cisplatin by electrochemical quartz crystal microbalance. Journal of Electroanalytical Chemistry 862, 113992. DOI: 10.1016/j.jelechem.2020.113992

Autoren:

S. K. K. Galagedera, Gerd-Uwe Flechsig