Laboratory for molecular cell biology

Brief description

The Laboratory for Molecular Cell Biology deals with questions of ageing research and rejuvenating medicine, multi-omics analytics, bioinformatics and molecular cell biology. The aim is to understand the ageing of cells and tissues in detail and to develop methods to reverse ageing and thus combat age-associated diseases. Transcriptome, proteome and metabolome analysis are combined to identify therapeutically relevant cellular processes and target molecules. The combination of bioinformatics and biological knowledge plays a central role here. In addition, assay systems for phenotypic screening using high-content imaging are developed and active substances are evaluated. The laboratory uses primary cell cultures, cell lines and complex three-dimensional cell models. The data is analyzed and integrated using bioinformatics.

Location: The Laboratory for Molecular Cell Biology is located in room 2-U41a.

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Laboratory equipment

  • CX5 CellInsight High Conten Screening Microscope
  • Cell culture technology (sterile workbenches, incubators, casy counters)
  • Abby Western Protein Analyzer
  • Zeiss fluorescence microscope
  • Ready-to-use pipelines for multi-omics analysis (transcriptome, proteome, metabolome)
Nahaufnahme einer Person mit blauen Handschuhen, die im Labor ein Mikroskop benutzt, wobei das Licht auf einen Objektträger unter der Linse fällt, was auf wissenschaftliche Forschung oder Laborarbeit hindeutet. at Hochschule Coburg Several translucent, pinkish spheres resembling biological cells float against a blue background, their complex molecular structures evoking the advanced studies and discoveries often found in modern laboratories. at Hochschule Coburg

Courses held in the laboratory

  • Practical course in cell culture technology

Techniques, methods and standards established in the laboratory

  • Cell culture of primary cells, cell lines and three-dimensional models
  • High-content screening and image analysis
  • Transcriptome analysis using NGS (RNA-Seq, small RNA-Seq)
  • Metabolome analyses (untargeted and targeted)
  • Proteome analyses
  • Isolation and characterization of exosomes from serum and cell cultures
  • Lentiviral expression systems for proteins and shRNAs
  • Transfection of siRNAs and shRNAs
  • Bioinformatics for the analysis of omics data sets
  • All common methods of molecular biology (cloning, western blot, qPCR, cytometry etc.)

Research and topics for cooperation

  • Age research
  • Rejuvenating biology / medicine
  • Transcriptome analyses
  • Metabolome analyses
  • Proteome analyses
  • High-content screening
  • Cell culture technology
  • Pharmacology
  • Dermatology

Laboratory management

A simple, gray user icon on a light gray background, featuring a circle for a head and a rounded rectangle for the shoulders and body, often used as a placeholder for profile pictures at Hochschule Coburg.
Prof. Dr. Janosch Hildebrand

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